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Wednesday Afternoon Lecture Series (WALS) - The two faces of the IL-15- Janus Kinase-Stat system: implications for the immunotherapy of autoimmune diseases and cancer

November 29, 2017

3:00pm - 4:00pm

Building 10, Clinical Center, Masur Auditorium

The NIH Director's Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus.

Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the United States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community.

The full WALS lecture season agenda is available at https://oir.nih.gov/wals.

William Paul Lecture

Speaker:

Thomas A. Waldmann, M.D.
NIH Distinguished Investigator
National Cancer Institute

Lecture summary:
Dr. Walmann will present the annual William Paul lecture. Dr. Waldmann defined the IL-2 receptor alpha and beta subunits using the daclizumab antibody he discovered, an antibody that is approved by the FDA. He co-discovered IL-15 and performed the first in-human clinical trial with this agent in patients with malignancy. Furthermore, Waldmann defined molecular abnormalities of the common gamma cytokine, Jak/Stat signaling pathway in HTLV-1 associated adult T-cell lymphoma and translated this discovery with a trial of a Jak inhibitor in patients with this disorder.

This lecture will be followed by a reception in the NIH Library. Special thanks to the Foundation for Advanced Education in the Sciences (FAES) for its support of the weekly reception. FAES is proud to co-sponsor with the NIH in hosting the Wednesday Afternoon Lecture Series.

To watch the lecture online, visit http://videocast.nih.gov. Registration is not required; seating is on a first-come, first-served basis. Fire regulations require that every person in Masur Auditorium must have a seat. Standing in the aisles or in the back of the auditorium is not permitted. Sign language interpreters can be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Jacqueline Roberts, Jacqueline.Roberts@nih.gov, 301-594-6747, or the Federal Relay, 800-877-8339.