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BIOL 039 | Epigenetics

December 7, 2020 to December 11, 2020

Registration occurs on a first-come, first-served basis. The deadline for registration is one week before the first day of the course.  If you are unable to register before the deadline, please email: registrar@faes.org or call 301-496-7977 for space availability. 

NIH Fellows or NIH community members being sponsored by their lab and awaiting payment authorization can tentatively hold a seat using the “Reserve A Seat” option. FAES must receive payment within 7 business days after reserving a seat or 3 business days before the start of the workshop, which ever comes first. If payment is not received in this time frame, your reservation will be canceled.

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Program Description
The sequencing of the human genome was not the endpoint of our goal of understanding human genomics. The chemical modifications to DNA, RNA, and the DNA-bound histone proteins, represent a second level of genetics-related biological control. These phenomena are often termed epigenetics (or epigenomics when evaluated genome-wide), and research has shown that epigenetic mechanisms provide an additional layer of biological control that regulates gene expression, chromatin organization, and DNA integrity.

This course will cover the basic principles of epigenetics, the role of epigenetic mechanisms in different organisms and animal model systems, the relevance of epigenetics to normal development and human disease, and the utilization of drugs and molecules that target epigenetic mechanisms. Furthermore, it provides a background that will facilitate a better understanding of the literature in this rapidly growing field. This course also aims to provide an understanding of epigenetic experimental design, and should, therefore, enable participants to incorporate epigenetic approaches into their research studies. 

Participating instructors are full-time researchers from neighboring institutes and universities who have been publishing in these areas for several years.

Topics
Lectures will cover basic mechanisms underlying DNA methylation, histone modification, chromatin organization, and noncoding RNA. Moreover, a broad range of applied epigenetic research topics will be covered, including cancer, development, environmental health, and immunology. The lectures also provide the participants with practical information concerning current techniques in epigenetic research. For example, the application of ChIP-Seq, ATAC-Seq, CHARM, Illumina bead arrays, restriction enzyme analysis, bisulfite sequencing, and RNA interference are discussed, and context is provided via descriptions of experimental design, data analysis, and interpretation and validation of results.

In the wet-lab, we will teach DNA extraction, bisulfite conversion, and quantitative methylation-specific PCR, which represent a core foundation for current next-generation sequencing approaches (such as BS-Seq) to methylation analysis.

The computational lab aims to provide an understanding of the bioinformatic approaches and computational methods used to analyze DNA methylation and chromatin data. Such approaches are relevant to the analysis of data from many cutting-edge technologies, and should prove useful for those interested in conducting a variety of epigenetic experiments and research projects.

Training Rate
$1,299.00 - General Rates - All others

Discounted Training Rates
$795.00 - NIH Trainees (Fellows, Postdocs, Postbacs, Grad students workng at any NIH campus)
$995.00 - NIH Community (Working, Appointed, or Assigned to NIH Campus)
$1,099.00 - Academia, US Goverment, US Military

Credit
Although no grades are given for Workshops, each participant will receive Continuing Education Units (CEUs) based on the number of contact hours. Upon completion of this 5-day program, each participant will receive 3.5 CEUs. Upon completion of each workshop, a certificate is issued.

Refund Policy
100% tuition refund for registrations cancelled 14 or more calendar days prior to the start of the workshop.
50% tuition refund for registrations cancelled between 4 to 13 calendar days prior to the start of the workshop.
No refund will be issued for registrations cancelled 3 calendar days or less prior to the start of the workshop.

Notification
All cancellations must be received in writing via email to Ms. Carline Coote at registration@faes.org.
Cancellations received after 4:00 pm (ET) on business days or received on non-business days are time marked for the following business day. 
All refund payments will be processed by the start of the initial workshop.

Suggested Lodging Accommodations
The Bethesdan by Hilton Hotel (formerly DoubleTree Bethesda)
8120 Wisconsin Avenue
Bethesda, MD 20814
+1-301-652-2000

  • Reservations 
    A special seasonal rate plus 13% tax for all workshop attendees is available at The Bethesdan by Hilton Hotel.  The rate includes complimentary in-room WiFi, breakfast buffet, $15 discounted overnight parking, and complimentary shuttle to and from the NIH campus.
    A credit card will be required to book the reservation. Cancellations must be made 48 hours prior to scheduled arrival to avoid a no-show charge. Check-in time is 3:00 p.m.; check-out is 12:00 p.m.

Book Online: The Bethesdan by Hilton
or Call: 1-844-382-7378 and ask for the "FAES Rate"

  • Location and Transportation 
    The Bethesdan is located within walking distance (0.8 miles) from the NIH main campus. Please inquire with the hotel directly regarding their shuttle schedule to/from the campus and other hotel amenities. The nearest Metro subway stops to the hotel are the Bethesda station (1 mile South of The Bethesdan) and Medical Center station (1 mile North of The Bethesdan), both on the Red line.

Access to the NIH Campus
All NIH visitors must enter through the Visitor’s Gateway Center (Bldg. 66) located at 9000 Rockville Pike-Rt. 355/Wisconsin Ave., Bethesda, MD. Taxi, bus, personal auto, and Uber/Lyft drop-off as well as the Medical Center (Red line) Metro subway station, a visitor’s parking garage (MLP-11), and access to the NIH campus shuttles are all located at this facility. Parking at the MLP-11 visitor’s garage is $12/day. 

NIH Security Screening
Please arrive early at the Visitor’s Gateway to allow for security screening which could take 10 to 30 minutes depending on the volume of campus visitors. You MUST show a valid government-issued photo ID (REAL ID* driver's license or passport).  Please visit the NIH website for helpful Visitor Information as well as directions, maps, campus shuttle schedules, and security screening information.
*REAL ID-Compliant Credentials are required for NIH visitors, effective October 1, 2020. 

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