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Wednesday Afternoon Lecture Series (WALS) - PROTAC-mediated protein gegradation: a new therapeutic modality

November 6, 2019

3:00pm - 4:00pm

Building 10, Clinical Center, Masur Auditorium

The NIH Director's Wednesday Afternoon Lecture Series, colloquially known as WALS, is the highest-profile lecture program at the NIH. Lectures occur on most Wednesdays from September through June from 3:00 to 4:00 p.m. in Masur Auditorium, Building 10 on the NIH Bethesda campus.

Each season includes some of the biggest names in biomedical and behavioral research. The goal of the WALS is to keep NIH researchers abreast of the latest and most important research in the United States and beyond. An added treat is the annual J. Edward Rall Cultural Lecture, which features top authors and other cultural icons. All speakers are nominated by the NIH community.

Speaker: Craig M. Crews, Ph.D.

Proteolysis Targeting Chimera (PROTACs) are the first of a new class of clinical drug candidates that work via a novel therapeutic paradigm, i.e., targeted protein degradation. These two-headed compounds recruit a target protein to be eliminated to an E3 ubiquitin ligase, leading to the tagging of the target protein for degradation by the cell’s own quality control system, the ubiquitin/proteasome system. PROTACs offer the ability to deliver on the therapeutic promise of siRNA (i.e., ability to target the undruggable proteome) but by using small molecules with more traditional drug-like properties.


This lecture will be followed by a reception in the NIH Library. Special thanks to the Foundation for Advanced Education in the Sciences (FAES) for its support of the weekly reception. FAES is proud to co-sponsor with the NIH in hosting the Wednesday Afternoon Lecture Series.

To watch the WALS lecture online, visit Registration is not required; seating is on a first-come, first-served basis. Fire regulations require that every person in Masur Auditorium must have a seat. Standing in the aisles or in the back of the auditorium is not permitted. Sign language interpreters can be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Jacqueline Roberts,, 301-594-6747, or the Federal Relay, 800-877-8339.